DB25-1205 Home stops

I am currently building a 3 axis machine and have just got round to worrying about the software bits. I have a 3D printer and this initially homes itself and then moves off to print when all is ready.
Is this useful on a 3 axis CNC machine and if so can i control this through the DB25-1205?
Obviously i need the DB25 to PC to respond to the limit switches in case of a fault.

Homing is very nearly mandatory for a CNC machine.

I've climbed a few more steps since i posted and am somewhat more aware of what is necessary. Thanks.