Is it possible to use Python to customize all interface?

Hi,everyone ,I'm going to build a machine with lathe and 4 axis milling function,and to the software developing part ,after reading the official doc of the linuxcnc .it looks that the linuxcnc could be used as a python module.So I'm going to use Python with Tkinter to bulid the GUI interface,and use the linuxcnc python module to control the machine,that's only a plan ,but I dont know if it can be really workable ? Has anyone done this like before ,welcome any advices or comments.Thanks

Sure, Axis gui uses python and tkinter (and also tcl) while gmoccpy gui uses python and gtk and qtdragon uses python and qt.

Thank you ,and I think the pure tkinter is too old-fasioned ,I 'd like to import some third part open-source lib such as CustomerTkinter, that looks better .

If it does not have to be tkinter maybe check also kivy?