-Work involved comes to pretty much the same, depending on tools at hand
-1 motor in general cheaper than two smaller ones as it does require also 2 drives for gantry squaring
-Moving mass again pretty close to same
-wiring more work for 2 motors
-configuration takes the same time, maybe tuning the squaring takes a bit more on the 2 motor setup
-on longer distances, the rotating shaft will vibrate at very low speeds, hence limiting velocities, or adding more support bearings along the way, and that in turn takes time to have the bearings lined up properly and adds more load to motor
-1 big motor cases more vibrations than 2 smaller ones, if using steppers
-2 motors and wiring makes the machine a bit more susceptible to interference, especially for Plasma
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Cant think of anything else for now...