I had a 'Force ON' assigned to output-00. This energized my estop circuit as soon as the 7i76e connected. Assigning ESTOP-Out to 7i76e-output-00 causes Axis to start with the gui estop button pressed.
Did you need that "net spindle-manual-stop <= hm2_7i76e.0.7i76.0.0.input-07" for something? If you wanted it, how did you have it wired up? That input was intended for a normally open momentary switch (button). If you had it connected to a switch or something that is normally closed, it would likely trigger on first start up.
It was wired to the 'zero-speed' relay output on my spindle drive. It was several months ago when I assigned that pin on one of my first passes through pncconf. Not sure what I was thinking.