I need an answer

Maybe these will help to see what is going on, I cannot start any GUI after I entered the command (sudo ethtool -C enp0s25 rx-usecs 0)Here is the error and report from that.

Well, you managed to change is to 10.10.10.1...

Its a bit hard to give help as it seems the GUI network configurators differ quite a bit depending on what's included with the specific Linux distribution you are using...

The alternate way (shown in the hm2_eth man page) allows you to set the ethtool option
and ip address in a way that is permanent (but not so friendly as the GUI network configurator)

The error you have means you cannot communicate with the FPGA card
(perhaps because the host IP address is still 10.10.10.10)

What does the command:

ip a

report?

I think this is what you want.  looking other post could it be the network needs to be turned on again 
I am using Debian 11 bullseye.
Then restart the network            ifdown -a; ifup -a

 

Yeah enp0s25 does not have a static (10.10.10.x) ip address setup so cannot
communicate with the FPGA card

You either need to beat the network GUI into submission or use the alternate method
of setting the IP address in the interfaces file

new data, It seems if you make a change in the network step up it take effect when you exit, not changing screens. I had entered 10.10.10.2 and then made that change in the Pncconf for the GUI QTPLasmaC and now it starts. I will check the GUI for axis now to see with that change if it will also work as far as starting up. still not sure about the original problem.

Note that you should not change _anything_ in LinuxCNC if you
are just changing the host IP address (The address in linuxCNC is the card address)

With communications working, you should now be able to test the IRQ coalescing

Axis still fails to start correctly. Time for a cool soda Thanks for your time.
Could there be a bad line in the HAL of INI file that got corrupted ???
Backups of QTPlasmaC and QTdragon will start up but not the original QTPlasmaC or Axis. I did a reconfigure for both and still will not start up for those 2.

Not likely corrupted (since LinuxCNC does not change these files)

What was the error?