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There are a lot more tuning settings required but lets get the main one
Can you type: echo $(nproc)
and then back in grub customizer add isolcpus=X where X = $(nproc)-1 from what is printed from the line above.
Then reboot.

My bad the PC is actually a HP Elitedesk 800 G1 USDT 
AMT is not disabled in BIOS where can I find those settings?   

OK a 8300 USDT uses Intel hardware and should be fine

Is AMT disabled in the BIOS?

So some background information my plasma table electronics and mesa 7i76e are not new the PC is new a newer HP elite 8300 USDT I swapped it out recently following issues with this post forum.linuxcnc.org/plasmac/53087-qtplasm...e-0-in-middle-of-cut 

I am not sure how do I find host hardware? 

is the

ip a

result still reasonable?

What is the host hardware?

I still get the same error after disabling eee 

The sudo grub-customizer did not disable eee for me.   

The reason ethtool is not found is that it's installed in /usr/sbin/
and that's not on the default user path. (but is in the default root path)

Its not working but i got everything to work.

github.com/mgiaco/ecam_cnc/ => axis
github.com/mgiaco/ecam_cnc/tree/probe_basic => probe basic

Now i am try to get manual tool change to work as i like.

once all that's done, do the ping command PCW asked for and share it. It should be pretty good now.

type: sudo ethtool --set-eee eno1 eee off

this will be lost on boot so to make it permanent
type
sudo grub-customizer
open the second tab and on the line it says quiet, add: igb.EEE=0
save and reboot. 
check eee is off again with ethtool

With energy efficient Ethernet enabled, sometimes your NIC has a holiday which is not good for latency

Also type man hm2_eth and follow the instructions so disable coalescing if you have not done that yet on your 10.10.10.1 NIC

sudo ethtool works 

I have several motor controllers that are driven by differential signals (CLK, #CLK, DIR, #DIR) – the inputs (5V, Ri = 120 Ohm) are not optically isolated. At first glance, it seems that controlling it with my Mesa 7i76EU works perfectly.

For testing purposes, I'd like to use the parallel port or possibly a RP2040 – in addition, I have a "Benezan Mini Breakout Board" left over from a previous setup that I could use.
It would be great if there were a solution for this.

probably needs sudo ethtool