Full disclosure I worked for Nvidia for 7+ years, left there in 2016.
My experience with the Nvidia parts has been pretty good with interrupt handling, so it looks like a good candidate. The GPIOs should be good for mutli-megahertz operation. I have pre-ordered one of the dev kits. I'm seeing an unstuffed battery clip on the back of the processor board, so I'm interested to see if there is an RTC supported on the board - may be in the SoC...
Should the onboard GPIO not be effective, there is an M.2 E-key slot which can be pulled out to a full-size x4 PCI-e slot with an
adapter
.
Unlike the RPi (even the 3 B+), the GPU on this should be able to wipe the floor with other SBCs for OpenGL support - but we'll see if the memory limitation of 4GB is going to kill us.
I have a Bridgeport Series 1 J-head I've been meaning to convert to CNC, with a tilt/rotate stage (5-axis). That'll be the target platform. NEMA42 4800oz-in @ 72V with Trinamic 10K-ppr encoders - just need Gecko to come out with a stepper+encoder drive...