The safest home position is with Z all the way up.
If the 0.25 is just for a tool change, think hard about all possible machine movement scenarios.
E.g clamps, workholding, tall work piece.
You don't want some g code to tell the machine to go to home (e.g. G53 X0Y0Z0) and smash into clamps etc.
The most common way to setup a machine is for Z0 to be at the top of the Z travel, and for all Z travel to be negative.
If you are not already familiar with the difference between
G53 / machine coordinates
G54-G59 / work coordinates
Then I suggest you read about them as it's very important to understand