A Widescreen Blender-Style Interface

That is looking nice !
And that lower right part would be nice to have the THC plasma stuff, or tool changer stuff, or diagnostics or..... never mind.

I want the entire left panel to be changeable for each mode of operation. For instance, if the user presses the "DRO Function" button, they would be able to do all the stuff they could do manually with a hardware DRO (such as dividing, bolt circles, drilling, single round or square pocket.) and the right panel "Code Runner" controls would be replaced with those DRO controls.

Many design programs have this modal panel on the right, but I wanted the Estop on the right, because most people are right handed, though, perhaps the right and left panels could be swapped for left-handed people, from an .ini file.

The Power and secondary on/offs would be on the right as well.

(No spindle (torch?) controls, yet.)

@tommylight, can you describe what's needed for a person with a plasma-cutter?
Perhaps, the on/off legends should be set up from the .ini file. I just want to make sure there are controls laid out for plasma, too.
For instance, can the "Spindle Speed" slider be used for plasma current, or "Laser Power"?
Can the "Flood" "Mist" controls be replaced with "Air" or "Co2" "Argon"

Drew spindle and accessory power buttons.
Realigned everything, keeping a consistent outer boarder for touchscreen.
Changed horizontal separator to newspaper style one.

Having more than one readout mode indicator is redundant, but I worry that the user might make a mistake. Hmmm.

So, I thought it would be handy to have a DRO, well, like a DRO : )
I thought it would be handing to do fastener spacing and bolt circles on the fly, perhaps a round and square pocket as well.

Anyway, the Gcode Runner window would be traded out for like this very preliminary drawing:

* Added Touch Buttons
* Added Tool button, but I don't like it
* Reworked Axis/Homing/Zero
* Removed Quick G-Keys for larger code view. To be moved to Manual Input
* Changed MDI to Manual Input, so new users would know what it is

I am not sure what order the items in tab menu should be?

I don't like that there are 2 "Edit"

Bolt circles are easy to MDI (not that having a GUI for it is a bad idea)